P. W. C.
When a susceptible subject is bitten by mosquitoes infected with malaria and containing sporozoites in their salivary glands, no symptoms appear until after an incubation period of about 10 days. With or slightly before the development of clinical symptoms, parasites first are found in the blood in demonstrable numbers. Until recently there were no direct observations of the parasites during the interval between inoculation and the appearance of parasites in the blood; and their location and activities have been a matter of speculation.
Schaudinn (1903) reported that after an infecting bite the sporozoites quite promptly penetrated into the red corpuscles,
P. W. C.. THE EXOERYTHROCYTIC CYCLE IN MALARIA. Ann Intern Med. 1949;30:1065–1069. doi: 10.7326/0003-4819-30-5-1065
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Published: Ann Intern Med. 1949;30(5):1065-1069.
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