ALVA A. KNIGHT, M.D., F.A.C.P.; JEANNE MILLER, B.S., M.S.
David, Phatak, and Zener,1 in 1943, published studies made on the toxicity and absorption of Iodochlorhydroxyquinoline (Vioform) and Diïodohydroxyquinoline (Diodoquin) in man. Their studies failed to include Iodoxyquinoline sulphonic acid (Chiniofon) also known as Anayodin or Yatren. Likewise, Diodoquin was not given in its recommended therapeutic dosage; therefore, the blood iodine levels and toxicity were not determined at therapeutic levels. Toxicity studies revealed both Vioform and Diodoquin to be relatively safe drugs since the recommended full therapeutic dosage in the thinnest individual is not over 8 mg. per kg. of Vioform and 30 mg. per kg. of Diodoquin. The lethal
KNIGHT AA, MILLER J. COMPARATIVE STUDIES ON THE IODINE ABSORPTION OF ANAYODIN, CHINIOFON, DIODOQUIN, AND VIOFORM IN MAN1. Ann Intern Med. ;30:1180–1187. doi: 10.7326/0003-4819-30-6-1180
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Published: Ann Intern Med. 1949;30(6):1180-1187.
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