JOSEPH C. PEDEN JR., M.D.
Splenomegaly is the common factor in a variety of syndromes of indefinite etiology in which leukopenia, anemia, and thrombocytopenia may be associated disorders. Splenomegaly and leukopenia in rheumatoid arthritis are well known under the name of Felty's syndrome. Chronic leg ulcers have frequently been described in splenomegalic syndromes, and we have recently encountered two cases presenting splenomegaly, atrophic arthritis, anemia, elevated basal metabolism rates, leukopenia with relative and absolute neutropenia, and chronic nonhealing leg ulcers.
Case 1. A 59 year old white male entered the hospital on April 2, 1945 complaining of an ulcer on the right shin
PEDEN JC. HYPERSPLENISM: TWO CASES WITH LEG ULCERS TREATED BY SPLENECTOMY1. Ann Intern Med. ;30:1248–1262. doi: 10.7326/0003-4819-30-6-1248
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Published: Ann Intern Med. 1949;30(6):1248-1262.
Hematology/Oncology, Hospital Medicine.
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