J. LAWRENCE POOL, M.D.
Prefrontal operations for the treatment of mental illness may be divided into two main classes: 1. those involving interruption of the white matter (lobotomy or leucotomy); 2. those involving resection of cortical gray matter (subtotal cortical ablation; frontal gyrectomy; topectomy).
The first effort to treat psychotic patients by surgery upon the brain was made by Burckhardt of Switzerland in 1891, who reported some degree of improvement following unilateral cortical ablations.1 Then in 1937, Moniz of Portugal2 reported encouraging results following bilateral prefrontal leucotomy, a procedure devised and developed by him, and later modified by Freeman and Watts who introduced it
POOL JL. PREFRONTAL OPERATIONS FOR THE TREATMENT OF MENTAL ILLNESS1. Ann Intern Med. 1949;31:424–428. doi: 10.7326/0003-4819-31-3-424
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Published: Ann Intern Med. 1949;31(3):424-428.
Hospital Medicine, Neurology.
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