H. J. L. M.
Since Withering1 established the empirical fact that the powdered leaves of foxglove were a valuable remedy for the dropsy, many of the pharmacological actions of digitalis have been elucidated. Those that have gained general acceptance are well summarized by Willius2 in three main compartments:
(a) digitalis depresses the function of the sino-auricular and the auriculo-ventricular nodes, and a tendency to slowing of the cardiac rate results;
(b) it depresses conduction throughout the cardiac muscle, particularly through the auriculo-ventricular bundle, and increases the refractory period in both the auricles and ventricles;
(c) it increases the amplitude of cardiac contraction and tends
M. HJL. NEW LIGHT ON THE PHARMACODYNAMICS OF HEART FAILURE. Ann Intern Med. ;31:524–528. doi: 10.7326/0003-4819-31-3-524
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Published: Ann Intern Med. 1949;31(3):524-528.
Cardiology, Heart Failure.
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