WARFIELD T. LONGCOPE, F.A.C.P.; JOHN A. LUETSCHER JR.
BAL (which stands for British Anti-Lewisite) or 2,3-dimercaptopropanol is a chemical found by Stocken and Thompson while working in Professor Peters' laboratory in Oxford, to be an effective antidote to Lewisite. This discovery made during the war represents the culmination of a long series of important investigations carried on for many years by several investigators, but especially by Professor Peters and his associates in Oxford.
For some time it had been known that the injurious effect of arsenic depends upon its attachment to the sulfhydryl groups of cellular proteins thus interfering with the function of essential enzymes which require the
LONGCOPE WT, LUETSCHER JA. THE USE OF BAL (BRITISH ANTI-LEWISITE) IN THE TREATMENT OF THE INJURIOUS EFFECTS OF ARSENIC, MERCURY AND OTHER METALLIC POISONS(THE USE OF BAL (BRITISH ANTI-LEWISITE) IN THE TREATMENT OF THE INJURIOUS EFFECTS OF ARSENIC, MERCURY AND OTHER METALLIC POISONS*). Ann Intern Med. 1949;31:545–554. doi: 10.7326/0003-4819-31-4-545
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Published: Ann Intern Med. 1949;31(4):545-554.
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