EDWARD A. GAENSLER; JOHN F. BEAKEY; MAURICE S. SEGAL, F.A.C.P.
Direct medication of the pulmonary epithelium is not a new development in therapeutics. It is readily understandable why interest in this accessible direct route of therapy should have developed during the early attempts to treat pulmonary disease. With the advent of successful specific oral and parenteral therapy, however, interest in primary medication of the lungs began to lag. The musculotropic and neurotropic action of bronchodilators, the belladonna group of alkaloids, and others, on the musculature and secretory cells of the bronchi was striking. Even more striking, however, was the immediate and prolonged relief afforded the asthmathic by the inhalation of
GAENSLER EA, BEAKEY JF, SEGAL MS. PHARMACODYNAMICS OF PULMONARY ABSORPTION IN MAN. I. AEROSOL AND INTRATRACHEAL PENICILLIN1. Ann Intern Med. ;31:582–594. doi: 10.7326/0003-4819-31-4-582
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Published: Ann Intern Med. 1949;31(4):582-594.
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