JOHN F. BEAKEY; EDWARD A. GAENSLER; MAURICE S. SEGAL, F.A.C.P.
The pharmacodynamics of pulmonary absorption has not been generally considered in the clinical reports on the success of aerosol and intratracheal therapy. There is equally meager information regarding the action of various pharmacologically active diluents in promoting or retarding absorption of penicillin from the pulmonary epithelium.
In a recent study1 we described various factors influencing absorption from the normal human lung. Crystalline penicillin G potassium (100,000 units) in physiologic saline was administered intramuscularly, intratracheally and by oxygen-aerosolization. The blood levels and urinary excretion, following intratracheal injection, were lower but more sustained than those following intramuscular administration. Rapid absorption would normally
BEAKEY JF, GAENSLER EA, SEGAL MS. PHARMACODYNAMICS OF PULMONARY ABSORPTION IN MAN. II. THE INFLUENCE OF VARIOUS DILUENTS ON AEROSOL AND INTRATRACHEAL PENICILLIN1. Ann Intern Med. ;31:805–820. doi: 10.7326/0003-4819-31-5-805
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Published: Ann Intern Med. 1949;31(5):805-820.
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