DANA C. MITCHELL, M.D.; R. W. VILTER, M.D., F.A.C.P.; C. F. VILTER, M.D.
Synthetic folic acid (pteroyl glutamic acid) has been used extensively in clinical investigation since November 1945 following reports of its effectiveness in the anemia of pernicious anemia, sprue and nutritional macrocytic anemia.1, 4 It has been available for general use during the past years and although it has been helpful in controlling the anemia of persons with pernicious anemia who developed hypersensitivity reactions to liver extract, it has failed to prevent the neurologic complications of pernicious anemia.5 Up to the time of writing hypersensitivity reactions to folic acid have not been noted though some persons who have received between 50
MITCHELL DC, VILTER RW, VILTER CF. HYPERSENSITIVITY TO FOLIC ACID1. Ann Intern Med. ;31:1102–1105. doi: 10.7326/0003-4819-31-6-1102
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Published: Ann Intern Med. 1949;31(6):1102-1105.
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