DAVID P. BARR, M.D., F.A.C.P.; GEORGE G. READER, M.D.; CHARLES H. WHEELER, M.D.
The term, cryoglobulinemia, was proposed by Lerner and Watson28 in 1947 in describing a patient whose serum contained a cold precipitable protein and whose presenting symptom was an extensive purpura that developed when he was exposed to the cold. They suggested that the designation of cryoglobulin be applied to any one of a group of proteins with the common property of precipitating or gelifying from cooled serum and that it include those proteins which in high concentration may precipitate at room temperature. Interest in the case of purpura led Lerner, Barnum and Watson26 to a search for similar proteins in
BARR DP, READER GG, WHEELER CH. CRYOGLOBULINEMIA. I. REPORT OF TWO CASES WITH DISCUSSION OF CLINICAL MANIFESTATIONS, INCIDENCE AND SIGNIFICANCE1. Ann Intern Med. ;32:6–29. doi: 10.7326/0003-4819-32-1-6
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Published: Ann Intern Med. 1950;32(1):6-29.
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