T. W. OPPEL, M.D., F.A.C.P.; CAROLYN COKER, M.D.; A. T. MILHORAT, M.D.
Since the report that an adrenal cortical hormone induces clinical improvement in the symptoms of rheumatoid arthritis,1 it has been suggested that other diseases with extensive involvement of collagen tissue might be similarly benefited. A supply of adrenocorticotropin (ACTH-Armour†) was made available to us for study in dermatomyositis and two patients have been treated. One patient who suffered also from advanced carcinomatosis received no apparent benefit from 12 days of treatment, but the effect on the other patient was dramatic. Improvement began within a few hours after the first dose, and the patient was transformed from a critical state into
OPPEL TW, COKER C, MILHORAT AT. THE EFFECT OF PITUITARY ADRENOCORTICOTROPIN (ACTH) IN DERMATOMYOSITIS1. Ann Intern Med. ;32:318–324. doi: 10.7326/0003-4819-32-2-318
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Published: Ann Intern Med. 1950;32(2):318-324.
Endocrine and Metabolism, Neurology, Pituitary Disorders, Rheumatology.
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