LOUIS K. ALPERT, M.D., F.A.C.P.; EZRA M. GREENSPAN, M.D.; STANLEY S. PETERSON, M.D.
The beta-chloroethyl amines, or nitrogen mustards, have been used since 19421-7 in the treatment of lymphomas as well as a variety of miscellaneous malignancies. It appears that, although no malignancy has been eradicated by the use of these chemical agents, some degree of temporary control has been effected in the clinical course of patients with Hodgkin's disease, the lymphosarcomas, chronic leukemias, polycythemia vera, transitional cell carcinomas, and in certain undifferentiated carcinomas of the lung and testis. Remissions in symptoms and reduction in size of tumor masses have been achieved in a significant proportion of the patients with these diseases. However,
ALPERT LK, GREENSPAN EM, PETERSON SS. THE TREATMENT OF THE LYMPHOMAS AND OTHER NEOPLASTIC DISEASES WITH NITROGEN MUSTARD1. Ann Intern Med. ;32:393–432. doi: 10.7326/0003-4819-32-3-393
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Published: Ann Intern Med. 1950;32(3):393-432.
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