ERNST A. POHLE, M.D., Ph.D.; IRVING WEISSMAN, M.D.
Since Cushing's4 original description in 1932 the syndrome of pituitary basophilism has become a well recognized entity. It is an uncommon disease which occurs more frequently in females than in males. The manifestations of the syndrome are painful obesity limited chiefly to the face, neck, shoulders and abdomen, thin reddish skin with purplish striae, acrocyanosis, hypertension and arteriosclerosis, kyphosis and backache with osteoporosis frequently resulting in multiple compression fractures of the vertebrae, weakness, amenorrhea in women, impotence in men, hirsutism without other evidence of virilism and hypoglycemia. The significant laboratory findings according to Albright1 are an unresponsive alimentary hyperglycemia, insulin
POHLE EA, WEISSMAN I. ROENTGEN THERAPY OF CUSHING'S SYNDROME (PITUITARY BASOPHILISM): REPORT OF A CASE OBSERVED FOR ELEVEN YEARS1. Ann Intern Med. ;32:542–548. doi: 10.7326/0003-4819-32-3-542
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Published: Ann Intern Med. 1950;32(3):542-548.
Adrenal Disorders, Endocrine and Metabolism.
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