MILTON S. SACKS
Complete extirpation of the dog pancreas by Minkowski and von Mering1 in 1889 may be viewed as the first approach to the production of experimental diabetes. It was this fundamental experiment which led, 33 years later, to the isolation of insulin by Banting and Best.2 Since 1922 further elucidation of the complexities of carbohydrate metabolism has been achieved by physiological experimentation. Numerous studies have led to the knowledge that the metabolic activity of these foodstuffs is not solely under the control of the beta cell hormone of the pancreas, but involves regulatory activities of other endocrine glands. Continuing apace with
SACKS MS. EXPERIMENTAL DIABETES. Ann Intern Med. 1950;32:572–576. doi: 10.7326/0003-4819-32-3-572
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Published: Ann Intern Med. 1950;32(3):572-576.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism.
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