JOHN J. BUTLER, M.D.; DAVID F. JAMES, M.D.
Multiple doses of Dicumarol have frequently been reported to cause major bleeding episodes. On the other hand, it has been often emphasized1, 2 that large single doses of Dicumarol given to normal animals and human beings cause marked prolongation of the prothrombin time but do not cause bleeding.
Herein is reported a case of major bleeding following a single dose of 300 mg. of Dicumarol in a patient with poor kidney function.
A 31 year old colored female was admitted to Grady Hospital on April 22, 1948, with the chief complaint of abdominal pain. Her illness had begun
JOHN J. BUTLER, DAVID F. JAMES. MAJOR BLEEDING RESULTING FROM A SINGLE DOSE OF DICUMAROL(MAJOR BLEEDING RESULTING FROM A SINGLE DOSE OF DICUMAROL*). Ann Intern Med. 1950;32:731–735. doi: 10.7326/0003-4819-32-4-731
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Published: Ann Intern Med. 1950;32(4):731-735.
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