MORRIS ZUCKERBROD, M.D.; IRVING GRAEF, M.D.
The significance of succinic acid in biologic oxidation and reduction is not fully understood. That it may be important is indicated by the fact that most normal tissues contain succinic dehydrogenase, which is very active and can account for the rapid oxidation of substrate amounts of succinate in tissue slices in vitro.1 Furthermore, the presence of succinate in the Krebs cycle can explain its rôle as a catalyst in the oxidation of carbohydrates and fats by certain tissue homogenates in vitro.2 The following scheme of relationships is generally accepted3:
In 1939, Quastel,4 investigating the mode of action of barbiturates, found
ZUCKERBROD M, GRAEF I. CLINICAL EVALUATION OF DISODIUM SUCCINATE, INCLUDING A REPORT ON ITS INEFFECTIVENESS IN TWO CASES OF SEVERE BARBITURATE POISONING AND SOME TOXICOLOGIC NOTES ON OTHER SUCCINATE SALTS(CLINICAL EVALUATION OF DISODIUM SUCCINATE, INCLUDING A REPORT ON ITS INEFFECTIVENESS IN TWO CASES OF SEVERE BARBITURATE POISONING AND SOME TOXICOLOGIC NOTES ON OTHER SUCCINATE SALTS*). Ann Intern Med. 1950;32:905–916. doi: 10.7326/0003-4819-32-5-905
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Published: Ann Intern Med. 1950;32(5):905-916.
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