ROBERT COHN, M.D.; CHARLES SAVAGE; GEORGE N. RAINES
In the process of recording from a large number of patients admitted to this hospital in comatose states, it has been observed that individuals rendered unconscious by barbiturate drugs present a remarkably homogeneous EEG pattern. This pattern can be clearly differentiated from the recordings obtained in comatose states induced by all other agents and pathophysiologic mechanisms that have come under our observation.
The characteristic EEG pattern of barbiturate intoxication consists of a random frequency high voltage type. Slow waves occur in isolated and short sequences of sinusoidal 160 to 250 millisecond waves and in nonsinusoidal (or complex sinusoidal) slower discharges
COHN R, SAVAGE C, RAINES GN. BARBITURATE INTOXICATION: A CLINICAL ELECTROENCEPHALOGRAPHIC STUDY1. Ann Intern Med. 1950;32:1049–1065. doi: 10.7326/0003-4819-32-6-1049
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Published: Ann Intern Med. 1950;32(6):1049-1065.
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