JOSEPH E. SMADEL, M.D.; CHARLES A. BAILEY, M.D.; RAYMOND LEWTHWAITE, M.D.
Although the efficacy of chloramphenicol (Chloromycetin 2) in the treatment of typhoid fever is now well established,1-8 there are many details which require further investigation. Accordingly, additional studies on the use of chloramphenicol in this disease were continued in Malaya by our group with the following purposes in view: (a) to compare the synthetic type of drug with the fermentation type which had been employed previously, (b) to determine the adequacy of treatment when given at various stages during the course of the disease, (c) to study the usefulness of simplified therapeutic regimens, and (d) to attempt to find means
SMADEL JE, BAILEY CA, LEWTHWAITE R. SYNTHETIC AND FERMENTATION TYPE CHLORAMPHENICOL (CHLOROMYCETIN) IN TYPHOID FEVER: PREVENTION OF RELAPSES BY ADEQUATE TREATMENT1. Ann Intern Med. ;33:1–17. doi: 10.7326/0003-4819-33-1-1
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Published: Ann Intern Med. 1950;33(1):1-17.
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