WILLIAM P. BOGER, F.A.C.P.; JOHN O. BEATTY, M.D.; FORREST W. PITTS, M.D.; HARRISON F. FLIPPIN, F.A.C.P.
The term chemotherapy is defined by Dorland as being "the treatment of disease by administering chemicals which affect the causative organism unfavorably but do not injure the patient." This definition implies that unless a chemical has antibacterial activity and unless it is administered for the treatment of disease caused by organisms, it cannot qualify as a "chemotherapeutic" agent. According to this limited definition of chemotherapy, the new compound p-(di-n-propylsulfamyl)-benzoic acid, 'Benemid,'2 is not itself a chemotherapeutic agent, but on the basis of data available at this time may be considered as an adjunct to chemotherapy with penicillin and para-aminosalicylic acid
BOGER WP, BEATTY JO, PITTS FW, FLIPPIN HF. THE INFLUENCE OF A NEW BENZOIC ACID DERIVATIVE ON THE METABOLISM OF PARA-AMINOSALICYLIC ACID (PAS) AND PENICILLIN1. Ann Intern Med. 1950;33:18–31. doi: 10.7326/0003-4819-33-1-18
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Published: Ann Intern Med. 1950;33(1):18-31.
Gout, Hospital Medicine, Infectious Disease, Rheumatology.
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