HARRIS ISBELL, M.D., F.A.C.P.
The purpose of this paper is to point out that chronic intoxication with barbiturates represents a true addiction—no matter how addiction is defined—and to describe the manifestations of maintained intoxication with barbiturates as well as the signs and symptoms which occur following withdrawal of these drugs from chronically intoxicated individuals.
The increasing incidence of acute intoxication with barbiturates is unquestioned. Production of the barbiturates in the United States has increased 400 per cent since 1933. In 1948, over 300 tons of these drugs were manufactured.1 Acute intoxication with barbiturates accounts for about 25 per cent of all cases of acute
ISBELL H. ADDICTION TO BARBITURATES AND THE BARBITURATE ABSTINENCE SYNDROME1. Ann Intern Med. 1950;33:108–121. doi: 10.7326/0003-4819-33-1-108
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Published: Ann Intern Med. 1950;33(1):108-121.
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