P. W. C.
Interest in the relationship of cholesterol to the development of arteriosclerosis dates from the demonstration by Aschoff more than 40 years ago that large amounts of cholesterol and other lipids are present in the atheromatous lesions of the aorta and its larger branches. This interest was greatly intensified by Anitschkow's report (1911) of the experimental production of similar atheromatous lesions in rabbits by feeding cholesterol for long periods. Anitschkow's observations have been abundantly confirmed, and a huge literature has accumulated on this subject.1, 2, 3 Although arterial lesions can be produced experimentally by other means, no other procedure has caused
C. PW. THE RELATION OF CHOLESTEROL TO THE DEVELOPMENT OF ATHEROSCLEROSIS. Ann Intern Med. ;33:250–258. doi: 10.7326/0003-4819-33-1-250
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Published: Ann Intern Med. 1950;33(1):250-258.
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