ROLAND P. MACKAY, M.D., F.A.C.P.
The question as to whether a constitutional "taint," predisposition or diathesis underlies the occurrence of multiple sclerosis has not yet been answered. The earlier neurologists, including Charcot, Gowers, Strümpell1 and Eduard Müller,2 considered that an endogenous or constitutional factor played an important rôle in the etiology of the disease. Its familial incidence, which might be expected if a constitutional tendency were operative, has nevertheless always been considered rare. In 1905 von Rad3 stated that "heredo-familial multiple sclerosis does not exist." Six years later E. Schultze4 softened the thought to "the greatest rarity." From that time to the present, increasing attention
MACKAY RP. THE FAMILIAL OCCURRENCE OF MULTIPLE SCLEROSIS AND ITS IMPLICATIONS1. Ann Intern Med. ;33:298–320. doi: 10.7326/0003-4819-33-2-298
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Published: Ann Intern Med. 1950;33(2):298-320.
Multiple Sclerosis, Neurology.
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