JONAH G. LI, M.D.; IRVIN G. VOTH, M.D.; EDWIN E. OSGOOD, M.D., F.A.C.P.
The pathogenesis of the hemolytic crisis, which occurs so precipitously in hereditary spherocytosis (congenital hemolytic jaundice), is unknown. However, it has been generally accepted that such crises are due to a sudden acceleration of hemolysis.1
Recently, Owren2 questioned this widely accepted view and proposed a new concept of the pathogenesis of the hemolytic crisis. He contended that the crisis is the result of aplasia of the bone marrow rather than an increased rate of hemolysis. His opinion is based on careful studies by serial blood and sternal marrow examinations of six patients observed through such crises. He noted leukopenia, thrombocytopenia
LI JG, VOTH IG, OSGOOD EE. HEMOLYTIC CRISIS IN HEREDITARY SPHEROCYTOSIS: STUDY OF A FAMILY OF FIVE WITH CONCURRENT CRISES1. Ann Intern Med. 1950;33:411–417. doi: 10.7326/0003-4819-33-2-411
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Published: Ann Intern Med. 1950;33(2):411-417.
Hematology/Oncology, Red Cell Disorders.
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