M. M. SWAN, Ph.D., M.D.; SAMUEL ZELMAN, M.D., F.A.C.P.
Miller and his co-workers1 have reported remissions produced in eight cases of acute lymphoblastic leukemia by the parenteral use of extracts of urine or stools from patients with chronic myeloid leukemia. The opportunity was recently afforded us of carrying out such therapy in a case of lymphoblastic leukemia that was hospitalized at a time when a patient with chronic myeloid leukemia was available. The result proved of considerable interest, and tends to confirm the findings of the aforementioned investigators.
The urine extract was prepared as described by Miller and Hause.2 A chloroform extract of acid-hydrolyzed urine was evaporated, reconstituted as
SWAN MM, ZELMAN S. MYELOKENTRIC ACID IN THE TREATMENT OF ACUTE LYMPHOBLASTIC LEUKEMIA1. Ann Intern Med. 1950;33:438–442. doi: 10.7326/0003-4819-33-2-438
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Published: Ann Intern Med. 1950;33(2):438-442.
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