JEROME A. COVEY, M.D.; JEROME L. COHEN, M.D.; JEAN P. PAPPS, M.D.
Since the description of the first case of idiopathic hypoprothrombinemia by Rhoads and Fitz-Hugh1 in 1941, 11 additional cases have been reported. While these cases presented hypoprothrombinemia as the cardinal feature, they exhibited other findings which indicate the overlapping of disorders of bleeding tendencies. Because of the paucity of established instances in the literature and the known variations in the bleeding and clotting tests, some doubt has been raised as to the existence of idiopathic hypoprothrombinemia as a disease entity. As it was only in 1935 that an accurate method for the determination of plasma prothrombin was first developed by
COVEY JA, COHEN JL, PAPPS JP. IDIOPATHIC HYPOPROTHROMBINEMIA1. Ann Intern Med. ;33:467–473. doi: 10.7326/0003-4819-33-2-467
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Published: Ann Intern Med. 1950;33(2):467-473.
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