HARRY EAGLE, M.D.; RALPH FLEISCHMAN; ARLYNE D. MUSSELMAN
Although penicillin is known to be actively bactericidal, there is reason to believe that its therapeutic activity is not determined solely by that direct bactericidal action, and that other factors may supervene in vivo. Thus, Jawetz6 found that, in a mouse streptococcal infection bacteria continued to die long after penicillin in demonstrable amounts had disappeared from the serum; and clinical experience has established the fact that penicillin is effective even when given so infrequently that for a considerable period between injections it is not present in bactericidal concentrations.11, 12, 13, 14 These observations would seem to minimize the importance of
EAGLE H, FLEISCHMAN R, MUSSELMAN AD. THE BACTERICIDAL ACTION OF PENICILLIN IN VIVO: THE PARTICIPATION OF THE HOST, AND THE SLOW RECOVERY OF THE SURVIVING ORGANISMS1. Ann Intern Med. ;33:544–571. doi: 10.7326/0003-4819-33-3-544
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Published: Ann Intern Med. 1950;33(3):544-571.
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