RICHARD E. WUNSCH, M.D.; ROBERT D. WARNKE, M.D.; GORDON B. MYERS, M.D., F.A.C.P.
The well known rôle of the sympathetic nervous system in hypertension has led to search for sympatholytic drugs for therapeutic purposes. An extensive study of the sympatholytic agent, N-N-dibenzyl-β-chlorethylamine (Dibenamine2) in experimental animals has revealed the following pharmacological effects:1, 2, 3, 4, 5, 6, 7, 8 (1) blockade of the usual pressor response to epinephrine and replacement by a depressor response; (2) prevention of ventricular tachycardia and fibrillation, ordinarily produced by toxic doses of epinephrine in dogs; (3) production of miosis and extension of the nictitating membrane in cats; (4) reduction of experimentally induced renal hypertension in rats and dogs;
WUNSCH RE, WARNKE RD, MYERS GB. THE EFFECTS OF DIBENAMINE ON SEVERE HYPERTENSION1. Ann Intern Med. 1950;33:613–628. doi: 10.7326/0003-4819-33-3-613
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Published: Ann Intern Med. 1950;33(3):613-628.
Cardiology, Coronary Risk Factors, Hypertension, Nephrology.
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