HAROLD H. JONES, M.D., F.A.C.P.; HAROLD H. JONES JR., M.D.; LEITHA D. BUNCH, M.A.
He consideration of multiple sclerosis as a metabolic disease is not new. The literature, both European and American, throws little light, however, on the chemical changes in this syndrome. Jelliffe1 in 1921 stated the possibility that the neurologic lesions were of metabolic origin. German investigators2, 3 reported elevated serum cholesterol values. In this country Brickner4 found abnormal lipolytic activity in the blood. Crandall and Cherry5 noted the similarity between the lipase activity in multiple sclerosis and in liver diseases. Weil and Cleveland6 likewise found abnormal serum lipase but did not consider it peculiar to the disease, since similar results were
JONES HH, JONES HH, BUNCH LD. BIOCHEMICAL STUDIES IN MULTIPLE SCLEROSIS1. Ann Intern Med. 1950;33:831–840. doi: 10.7326/0003-4819-33-4-831
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Published: Ann Intern Med. 1950;33(4):831-840.
Multiple Sclerosis, Neurology.
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