C. C. SHULLENBERGER, M.D.; CHARLES H. WATKINS, M.D., F.A.C.P.
Since there is as yet no knowledge of the cause of the increased rate of erythrocyte production in polycythemia vera, the most desirable therapeutic agent for this disease, from a theoretical standpoint, is one which can be given in dosage sufficient to depress the abnormal rate of mitosis in the erythropoietic tissue without seriously affecting the bone marrow cells which give rise to the granulocytes and platelets. At present, it is believed that the agent which most nearly fulfills these criteria is irradiation, by means either of roentgen-rays or of radioactive phosphorus. Recently, however, nitrogen mustard has received attention as
SHULLENBERGER CC, WATKINS CH. EFFECTS OF NITROGEN MUSTARD ON THE BONE MARROW IN POLYCYTHEMIA VERA1. Ann Intern Med. ;33:841–853. doi: 10.7326/0003-4819-33-4-841
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Published: Ann Intern Med. 1950;33(4):841-853.
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