BURTON A. WAISBREN, M.D.; WESLEY W. SPINK, M.D., F.A.C.P.
Neomycin, an antibiotic derived from a strain of streptomycetes that is closely related to Streptomycetes fradiae, was discovered by Waksman and Lechevalier in 1949.1 It was a product of their search for an antibiotic that would be effective against streptomycin-resistant bacteria, particularly tubercle bacilli. Little has been reported as to the chemical nature of neomycin other than that it is a basic compound, heat stable, and is resistant to the action of acid (pH 2) at the temperature of boiling water.1
Studies on the spectra of bacteria affected by neomycin have revealed the drug to be bactericidal in vitro against
WAISBREN BA, SPINK WW. A CLINICAL APPRAISAL OF NEOMYCIN(A CLINICAL APPRAISAL OF NEOMYCIN*). Ann Intern Med. 1950;33:1099–1119. doi: 10.7326/0003-4819-33-5-1099
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Published: Ann Intern Med. 1950;33(5):1099-1119.
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