JOSEPH B. VANDER VEER, M.D., F.A.C.P.; P. T. KUO, M.D.; DAVID S. MARSHALL II, M.D.
Organic mercurial compounds are the most powerful diuretics known. They have become an important agent in the treatment of edema, especially that of chronic congestive heart failure. DeGraff and his associates have shown that the addition of a theophylline group to the mercurial compounds enhances the diuretic effect of these substances and reduces their toxicity.1 The three currently used preparations containing theophylline—Mercuzanthin, Salyrgan-theophylline, and Mercuhydrin—possess local irritating properties and require deep intramuscular or intravenous injections. With these routes of administration, a number of severe local reactions2 and fatal cardiac toxicity1, 3, 4, 5, 6 have been reported with the use
VANDER VEER JB, KUO PT, MARSHALL DS. CLINICAL EXPERIENCES WITH A NEW MERCURIAL DIURETIC FOR SUBCUTANEOUS ADMINISTRATION1. Ann Intern Med. 1950;33:1215–1223. doi: 10.7326/0003-4819-33-5-1215
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Published: Ann Intern Med. 1950;33(5):1215-1223.
Cardiology, Hospital Medicine.
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