C. F. GUTCH, M.D.
Adequate therapy of amebiasis—the human infection by Endamoeba histolytica—demands treatment of possible systemic as well as intestinal infection.1, 2 Since the use of ipecac early in the Nineteenth Century, the search for more effective drugs has continued; however, despite introduction of improved therapeutic agents, a significant failure rate and also a definite incidence of toxicity have not been eliminated.
Drugs which have been used against amebiasis include:
1. Emetine group—ipecac, emetine, and emetine bismuth iodide.
2. Oxyquinoline derivatives—Chiniofon, Vioform, Diodoquin, Chloroquine, Win 246 and Win 1011.
3. Organic arsenicals (pentavalent arsenicals)—carbarsone, Treparsol, Acetarsone. (The trivalent analogues of carbarsone with substituted
GUTCH CF. THE TREATMENT OF AMEBIASIS, WITH A PRELIMINARY REPORT ON THE USE OF AUREOMYCIN1. Ann Intern Med. ;33:1407–1412. doi: 10.7326/0003-4819-33-6-1407
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Published: Ann Intern Med. 1950;33(6):1407-1412.
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