JOSEPH E. SMADEL; HERBERT L. LEY JR.; FRED H. DIERCKS
Chloramphenicol now has an established place in the treatment of typhoid fever.1, 2, 3, 4, 5 However, it has been our observation, as well as that of others, that little if any clinical improvement occurs during the first 36 hours of therapy and that the patients do not become afebrile until about the fourth day. This delay in therapeutic response is difficult to explain, since previous experience shows that the bacterial organisms are promptly controlled by specific therapy.3 Indeed, the bacteremia ceases several days before fever and toxemia subside. However, it has seemed reasonable to postulate that the delayed clinical
SMADEL JE, LEY HL, DIERCKS FH. TREATMENT OF TYPHOID FEVER. I. COMBINED THERAPY WITH CORTISONE AND CHLORAMPHENICOL1. Ann Intern Med. 1951;34:1–9. doi: 10.7326/0003-4819-34-1-1
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Published: Ann Intern Med. 1951;34(1):1-9.
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