WILLIAM E. RICKETTS, M.D., Ph.D.
The pathogenesis, as well as the treatment, of edema and ascites in portal cirrhosis has been a subject of utmost interest and continuous investigation. Attention has been directed to the rôle of proteins and the colloid osmotic pressure of the plasma,1, 2, 3, 4, 5, 6, 7, 8, 9 to disturbances in electrolyte excretion10, 11, 12 and to urine output.6 Previous studies have shown that the plasma albumin was consistently within the normal range in patients with latent, asymptomatic cirrhosis,13, 14 whereas it was consistently reduced in patients with portal cirrhosis accompanied by severe jaundice and ascites. Clinical improvement following
RICKETTS WE. OBSERVATIONS ON PORTAL CIRRHOSIS WITH ASCITES1. Ann Intern Med. ;34:37–60. doi: 10.7326/0003-4819-34-1-37
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Published: Ann Intern Med. 1951;34(1):37-60.
Gastroenterology/Hepatology, Liver Disease, Tobacco, Alcohol, and Other Substance Abuse.
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