H. M. MARGOLIS, M.D., F.A.C.P.; PAUL S. CAPLAN, M.D.
The striking observations reported by Hench, Kendall, Slocumb and Polley1 of the beneficial effect of daily administration of 17-hydroxy-11-dehydrocorticosterone (compound E, cortisone), and of pituitary adrenocorticotropic hormone (ACTH) in rheumatoid arthritis, have presented the brightest hope for alleviation of the manifestations of this serious disease. However, lack of sufficient knowledge of the long-range metabolic effects of these potent hormones and their present unavailability for general therapeutic use have stimulated an avid search for some related steroid which may duplicate or approach the effectiveness of the agents employed by Hench.
Testosterone propionate is a steroid chemically related to cortisone. In large
MARGOLIS HM, CAPLAN PS. THE EFFECT OF SOME STEROIDS (TESTOSTERONE PROPIONATE, DESOXYCORTICOSTERONE ACETATE AND ASCORBIC ACID, AND 21-ACETOXY Δ-5-PREGNENOLONE, ARTISONE ACETATE, WYETH) IN RHEUMATOID ARTHRITIS(THE EFFECT OF SOME STEROIDS (TESTOSTERONE PROPIONATE, DESOXYCORTICOSTERONE ACETATE AND ASCORBIC ACID, AND 21-ACETOXY Δ-5-PREGNENOLONE, ARTISONE ACETATE, WYETH) IN RHEUMATOID ARTHRITIS*). Ann Intern Med. 1951;34:61–71. doi: 10.7326/0003-4819-34-1-61
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Published: Ann Intern Med. 1951;34(1):61-71.
Rheumatoid Arthritis, Rheumatology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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