C. RAY WOMACK, M.D.; CHARLES B. REINER, M.D.
Streptomycin was first described over five years ago by Waksman and his coworkers.21 As experience has accumulated regarding its clinical use, manifestations of toxicity have become increasingly and significantly apparent. Depression of the blood-forming organs has been, however, an uncommon occurrence, and only two previous cases of aplastic anemia due to streptomycin are known to have been reported at the time of this communication.
Little evidence of toxic effects of streptomycin administration upon the hematopoietic system has been observed in animal studies. Feldman and Hinshaw10 noted no effect on hematopoietic tissues or hemoglobin values in tuberculous guinea pigs treated for
WOMACK CR, REINER CB. FATAL APLASTIC ANEMIA DUE TO STREPTOMYCIN: CASE REPORT AND BRIEF REVIEW OF PERTINENT LITERATURE(FATAL APLASTIC ANEMIA DUE TO STREPTOMYCIN: CASE REPORT AND BRIEF REVIEW OF PERTINENT LITERATURE*). Ann Intern Med. 1951;34:759–767. doi: 10.7326/0003-4819-34-3-759
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Published: Ann Intern Med. 1951;34(3):759-767.
Hematology/Oncology, Red Cell Disorders.
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