THOMAS W. GREEN, M.D.; C. LOCKARD CONLEY, M.D.
The occurrence of bone and joint pain, abdominal pain, jaundice and other symptoms in patients with sicklemia has generally been associated with the presence of persistent anemia. According to general belief, individuals who are found to have the sickle cell trait in the absence of anemia do not subsequently develop manifestations of the disease. On the other hand, persons with sickle cell anemia are not believed to undergo remissions so complete that the blood picture becomes normal.1
In 1929 Levy2 reported three cases of supposed sickle cell disease with periods of symptoms and anemia followed by intervals in which normal
GREEN TW, CONLEY CL. OCCURRENCE OF SYMPTOMS OF SICKLE CELL DISEASE IN THE ABSENCE OF PERSISTENT ANEMIA1. Ann Intern Med. ;34:849–855. doi: 10.7326/0003-4819-34-4-849
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Published: Ann Intern Med. 1951;34(4):849-855.
Hematology/Oncology, Red Cell Disorders.
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