RICHARD T. BEEBE, M.D., F.A.C.P.; SIMON PROPP, M.D.; JOHN C. MCCLINTOCK, M.D.; ARMAND VERSACI, M.D.
The introduction of antithyroid drugs as therapeutic agents for the treatment of toxic goiter led to the belief that surgery would no longer be necessary to relieve hyperthyroidism. The accumulated experience of the past seven years has failed to support initial hopes and, in addition, has indicated certain hazards associated with the use of these drugs. Although new and less toxic forms of the original antithyroid agent have been developed, they cannot be used indiscriminately.
A few carefully selected patients can obtain a cure of their hyperthyroidism from the judicious use of antithyroid agents alone. Many patients undergo thyroidectomy with
BEEBE RT, PROPP S, MCCLINTOCK JC, VERSACI A. FATAL AGRANULOCYTOSIS DURING TREATMENT OF TOXIC GOITER WITH PROPYLTHIOURACIL1. Ann Intern Med. 1951;34:1035–1040. doi: 10.7326/0003-4819-34-4-1035
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Published: Ann Intern Med. 1951;34(4):1035-1040.
Endocrine and Metabolism, Thyroid Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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