LOUIS BAUMAN; JOSE L. R. CANDELA; TERRY MARTINO
Can continuous careful control of diabetes prevent the degenerative complications of the disease? This controversial question, though uppermost in the minds of diabetic therapists, has never been subjected to satisfactory animal experimentation.
The alloxan diabetic dog offers an approach to this problem because alloxan selectively destroys the islands of Langerhans and because the dog is best suited for this purpose.
It was planned to produce the disease and then maintain the animals in metabolism cages on the proper diet and insulin dosage for an extended period of time. Unfortunately, we were limited to a small number of animals, but the
BAUMAN L, CANDELA JLR, MARTINO T. PROLONGED REGULATION OF ALLOXAN DIABETES IN DOGS1. Ann Intern Med. ;35:391–396. doi: 10.7326/0003-4819-35-2-391
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Published: Ann Intern Med. 1951;35(2):391-396.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism.
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