JOSEPH H. HOLMES, M.D., F.A.C.P.; S. C. PERCEFULL, M.D.
The study dealt with herein was undertaken to determine if any of the usual clinical liver function tests change in any way under cortisone therapy. It is well known that the adrenal cortex is concerned with protein,1, 2 glucose3 and fat4, 5 metabolism. It has even been reported that the administration of ACTH will produce a fatty liver in the experimental animal, although this can be prevented by the administration of glucose.4 Furthermore, patients with Cushing's syndrome frequently have hypercholesteremia, and patients with adrenal insufficiency tend to a low serum cholesterol.7 A marked hypercholesteremia was observed in rabbits after adrenal
HOLMES JH, PERCEFULL SC. LIVER FUNCTION STUDIES DURING CORTISONE THERAPY1. Ann Intern Med. ;35:608–614. doi: 10.7326/0003-4819-35-3-608
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Published: Ann Intern Med. 1951;35(3):608-614.
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