DWIGHT J. INGLE, Ph.D.
The size and the secretory activity of the adrenal cortex are controlled to a major extent by the adrenocorticotropic hormone (ACTH) of the anterior pituitary. The anterior pituitary adjusts its output of ACTH to meet the physiologic "needs" of the organism for cortical hormones. This paper is a review of some of the laboratory and clinical observations bearing upon this interrelationship. Some of the illustrations are drawn from my own laboratory data and experiences.
The fact that hypophysectomy causes atrophy of the adrenal cortex was first demonstrated by Allen1 and Smith2 in
DWIGHT J. INGLE. THE FUNCTIONAL INTERRELATIONSHIP OF THE ANTERIOR PITUITARY AND THE ADRENAL CORTEX(THE FUNCTIONAL INTERRELATIONSHIP OF THE ANTERIOR PITUITARY AND THE ADRENAL CORTEX*). Ann Intern Med. 1951;35:652–672. doi: 10.7326/0003-4819-35-3-652
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Published: Ann Intern Med. 1951;35(3):652-672.
Adrenal Disorders, Endocrine and Metabolism.
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