HERBERT C. MODLIN, M.D.; WALTER DEM. SCRIVER, M.D., F.A.C.P.
The hypothalamus has been suggested as the anatomic locus for many diseases and syndromes, two of which are narcolepsy and diabetes insipidus. Evidence that diabetes insipidus originates here is convincing. It has been established both clinically3 and experimentally10, 20 that this syndrome results from a lesion of the hypothalamico-hypophysial tract. Specifically, bilateral destruction of the supraoptic nuclei produces diabetes insipidus although high section of the infundibular stalk may do the same. Removal of the posterior lobe of the pituitary gland does not result in water imbalance. In sleep disturbances of the narcoleptic type we are less certain of the etiology,
MODLIN HC, SCRIVER WD. RECOVERY FROM REFRACTORY DIABETES INSIPIDUS ASSOCIATED WITH NARCOLEPSY1. Ann Intern Med. ;35:710–717. doi: 10.7326/0003-4819-35-3-710
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Published: Ann Intern Med. 1951;35(3):710-717.
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