W. W. PRIDDLE, M.D., F.A.C.P.
Evidence is gradually accumulating that the genesis of human atherosclerosis is somehow associated with cholesterol metabolism. Myxedema, poorly-controlled diabetes, xanthomatosis and nephrosis have in common a high serum cholesterol, and they are prone to develop premature and severe grades of atherosclerosis.
Anitschkow1 in 1912, by feeding rabbits pure cholesterol dissolved in a vegetable oil, was successful in producing experimental atherosclerosis. In 1933 he expressed the opinion, in reviewing the literature up to that time, that the experimental lesions in rabbits were the same as those of human atherosclerosis. Duff2 stated in 1935, in an extensive review, that there was insufficient
PRIDDLE WW. HYPERCHOLESTEREMIA: AN ANALYSIS OF 529 CASES AND TREATMENT OF 297 BY A LOW ANIMAL FAT DIET AND DESICCATED THYROID SUBSTANCE1. Ann Intern Med. ;35:836–847. doi: 10.7326/0003-4819-35-4-836
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Published: Ann Intern Med. 1951;35(4):836-847.
Cardiology, Coronary Risk Factors, Dyslipidemia.
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