CHARLES G. CRADDOCK JR., M.D.
Hemolytic destruction of red blood cells as a result of the activity of circulating agglutinins and hemolysins is often encountered clinically. The antigenic stimulus for the sudden appearance of these abnormal antibodies in various types of transfusion reactions is well understood and their presence is usually demonstrable by in vitro technics. In the case of idiopathic acquired hemolytic anemia, however, the immunologic processes are not understood. The classic work of Dameshek and Schwartz1 leaves little doubt that the presence of hemolysins or agglutinins plays an important part in the pathologic destruction of red cells in these cases. Similar findings have
CHARLES G. CRADDOCK. ACUTE IDIOPATHIC HEMOLYTIC ANEMIA: REPORT OF A SEVERE FATAL CASE WITH IMMUNOLOGIC OBSERVATIONS(ACUTE IDIOPATHIC HEMOLYTIC ANEMIA: REPORT OF A SEVERE FATAL CASE WITH IMMUNOLOGIC OBSERVATIONS*). Ann Intern Med. 1951;35:912–918. doi: 10.7326/0003-4819-35-4-912
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Published: Ann Intern Med. 1951;35(4):912-918.
Hematology/Oncology, Red Cell Disorders.
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