ALEXANDER GOTZ, M.D.
In recent years, heparin has found wide clinical use as an effective agent in the prevention and treatment of thromboembolic disease.
Heparin is a complex organic substance containing chondroitinsulfuric acid and small amounts of protein (1 to 2 per cent).1 It is usually obtained from beef liver or lung. It would therefore seem quite likely that a fairly large number of cases of sensitivity to this substance would be encountered in clinical practice. Surprisingly, however, the literature contains comparatively few reports of heparin sensitivity.
Jorpes2 mentioned four cases in his comprehensive monograph, without going into detail about them. Hojensgard and
ALEXANDER GOTZ. SEVERE SPONTANEOUS HYPERSENSITIVITY TO HEPARIN(SEVERE SPONTANEOUS HYPERSENSITIVITY TO HEPARIN*). Ann Intern Med. 1951;35:919–922. doi: 10.7326/0003-4819-35-4-919
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Published: Ann Intern Med. 1951;35(4):919-922.
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