ISIDORE FISCHER, M.D.
Serum sickness has been estimated to follow the injection of various sera in about 15 per cent of all cases in which they are used.1 There is no known method of preventing it, nor is there any way of identifying the persons likely to develop it. The whole subject, in fact, remains in need of clarification. It was originally attributed to the presence of antibodies in the serum, but that assumption, as Doyle2 notes, was promptly disposed of when Johannessen demonstrated that the reaction also occurred following the injection of horse serum alone. Although the exact cause is still to
FISCHER I. SERUM NEURITIS1. Ann Intern Med. ;35:922–926. doi: 10.7326/0003-4819-35-4-922
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Published: Ann Intern Med. 1951;35(4):922-926.
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