WILLIAM H. BLAHD, M.D.; MARVIN S. LEVY, M.D.; SAMUEL H. BASSETT, M.D.
In 1893, under the title "General Tuberculosis," Hand1 reported a case of a three year old child with a peculiar skin eruption, skull defects and yellow nodules in the liver and spleen. Kay2 in 1905 described diabetes insipidus, skull defects and exophthalmos in a seven year old child, which he termed "acquired hydrocephalus with atrophic bone changes." Some years later Schüller3 and Christian4 described cases exhibiting essentially the same clinical manifestations, and attributed these changes to pituitary dysfunction. This original concept was altered, however, by the histologic studies of Rowland5 in 1928, which indicated that the syndrome was related to
BLAHD WH, LEVY MS, BASSETT SH. A CASE OF HAND-SCHÜLLER-CHRISTIAN SYNDROME TREATED WITH CORTISONE1. Ann Intern Med. 1951;35:927–937. doi: 10.7326/0003-4819-35-4-927
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Published: Ann Intern Med. 1951;35(4):927-937.
Neurology, Pulmonary/Critical Care.
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