H. E. HALL; J. A. HIGHTOWER; R. DIAZ RIVERA, M.D.; R. J. BYRNE; J. E. SMADEL, M.D.; T. E. WOODWARD, M.D.
Prior to the advent of antibiotics, many agents were employed for the therapy of leptospirosis. Walch-Sorgdrager1 some years ago reviewed the earlier literature which described the use of arsenical and bismuth compounds and of immune serum. In brief, none of these earlier remedies has stood the test of time. Moreover, sulfonamides were devoid of therapeutic value.1-4 Recently numerous investigators have described the beneficial effects of penicillin in human cases. Bulmer,5 Patterson4 and Suchett-Kaye6 concluded that this antibiotic when used during the early stages of leptospirosis, i.e., before the onset of jaundice, was markedly effective in reducing fever, lessening the severity
HALL HE, HIGHTOWER JA, RIVERA RD, BYRNE RJ, SMADEL JE, WOODWARD TE. EVALUATION OF ANTIBIOTIC THERAPY IN HUMAN LEPTOSPIROSIS1. Ann Intern Med. 1951;35:981–998. doi: 10.7326/0003-4819-35-5-981
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Published: Ann Intern Med. 1951;35(5):981-998.
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