MACALLISTER W. JOHNSTON; A. H. SQUIRES; R. F. FARQUHARSON, F.A.C.P.
The beneficial effects of continued thyroid therapy in patients suffering from myxedema are remarkable and persistent. On administration of relatively small doses, the basal metabolic rate rises and remains within normal limits as long as the therapy is continued. The symptoms and signs of myxedema disappear and do not recur; sometimes a slightly higher dosage of thyroid is required with the passage of time, but the effectiveness of the drug does not change materially. (See figure 1.) On the other hand, as was pointed out in a former report,1 it is often difficult by the administration of similar amounts
JOHNSTON MW, SQUIRES AH, FARQUHARSON RF. THE EFFECT OF PROLONGED ADMINISTRATION OF THYROID1. Ann Intern Med. ;35:1008–1022. doi: 10.7326/0003-4819-35-5-1008
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Published: Ann Intern Med. 1951;35(5):1008-1022.
Endocrine and Metabolism, Thyroid Disorders.
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