SALVATORE M. SANCETTA, M.D.; PERRY R. AYRES, M.D.; ROY W. SCOTT, M.D., F.A.C.P.
The purpose of this paper is to report our experiences with the use of parenterally administered vitamin B12 in the management of 12 diabetic patients exhibiting unquestioned neurologic manifestations associated with the disease. We shall not discuss the features of so-called "diabetic neuropathy," other than for the corollaries necessary to our thesis. The reader interested in a detailed presentation of the subject is referred to the classical monograph of Rundles,15 as well as to other excellent treatises available in the literature.3, 14, 16
Vitamin B12 has been found to arrest6 and reverse2 the neurologic changes in patients with pernicious anemia,
SANCETTA SM, AYRES PR, SCOTT RW. THE USE OF VITAMIN B12 IN THE MANAGEMENT OF THE NEUROLOGIC MANIFESTATIONS OF DIABETES MELLITUS, WITH NOTES ON THE ADMINISTRATION OF MASSIVE DOSES1. Ann Intern Med. ;35:1028–1048. doi: 10.7326/0003-4819-35-5-1028
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Published: Ann Intern Med. 1951;35(5):1028-1048.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism.
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